Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy.
نویسندگان
چکیده
Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
منابع مشابه
Intracellular “activated” two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer
The application of photodynamic therapy (PDT) for the diagnosis and treatment of cancer is hindered by the intrinsic defects of the currently available photosensitizers (PSs), such as poor water solubility and limited light-penetration depth. In this study, pH-responsive polymeric micelles that co-encapsulate therapeutic PSs and organooxotin two-photon compounds were applied for two-photon PDT ...
متن کاملPolymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluro...
متن کاملPhotosensitization of coronene–purine hybrids for photodynamic therapy
Photosensitization properties of coronene-purine (Cor-P) hybrids for photodynamic therapy (PDT) have been investigated in this work. Eight hybrid Cor-P models have been designed by the additional of adenine (A) and guanine (G) nucleobase to Cor species. The evaluated absorption and emission energies indicated that the singular models are not good at all for PDT process whereas their hybrid mode...
متن کاملAmphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment.
The light-triggered controlled release of anticancer drugs accompanied with NIR-responsive photodynamic therapy was prepared via a self-assembly process. Firstly, Mn(2+)-doped upconversion nanoparticles (UCNPs) were coated with a mesoporous silica shell and modified with photosensitizer (Chlorin e6) and long alkyl chains. And then the NIR light-responsive amphiphilic copolymer containing 9,10-d...
متن کاملLight-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity
We developed light-triggered liposomes incorporating 3-5 nm hydrophobic gold nanoparticles and Rose Bengal (RB), a well-known photosensitizer used for photodynamic therapy. Singlet oxygen generated by these liposomes with 532 nm light illumination was characterized for varying the molar ratio of lipids and gold nanoparticles while keeping the amount of RB constant. Gold nanoparticles were found...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 51 49 شماره
صفحات -
تاریخ انتشار 2015